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December 1, 2025Open Access

Quantifying Structural Selection Bias in Observational Cohort Data: A Ponderation Analysis of Age- Specific Incidence Rates to Inform Vaccine Safety Verification

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Ponderation analysis reveals substantial methodological flaws impacting internal and external validity of COVID-19 vaccine safety assessments.

The observed HR of 2.714 significantly underestimates vaccine safety due to structural selection bias.
Correcting for age distribution yields an HR Corrected near unity, indicating no increased risk of Vitiligo post-vaccination.
Ponderation analysis across age cohorts highlights systemic methodological failures in the original findings.
Results underscore the need for stringent evaluation of observational data to avoid misleading conclusions on vaccine safety.

Roccetti, Marco (2025) studied this question.

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Ponderation analysis reveals substantial methodological flaws impacting internal and external validity of COVID-19 vaccine safety assessments.