December 1, 2025Clinical Case ReportsOpen Access

Unusual Presentation of Subcutaneous Panniculitis‐Like T‐Cell Lymphoma

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Discussion

Case report reveals atypical lymphocytic infiltration with SPTCL symptoms in a 40-year-old female, indicating urgent diagnosis is critical.

Initial misdiagnosis as erythema nodosum led to ineffective treatment with antibiotics and corticosteroids, underscoring diagnostic challenges.
Comprehensive histopathological and immunohistochemical evaluation confirmed atypical lymphocytic infiltration consistent with SPTCL.
The patient's systemic symptoms included weight loss and fatigue, complicating the differential diagnosis process.
This case emphasizes the need for prompt histopathological assessment in atypical panniculitis-like lesions to improve management.

Alkallabi et al. (2025) studied this question.

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Case report reveals atypical lymphocytic infiltration with SPTCL symptoms in a 40-year-old female, indicating urgent diagnosis is critical.