COCOMAPS 2.0: a web server for identifying, analyzing and visualizing atomic interactions at the interface of biomolecular complexes

Summary Herein we present COCOMAPS 2.0, for the analysis, visualization, and comparison of the interface in protein–protein and protein–nucleic acid complexes. COCOMAPS 2.0 complements the residue-level and buried surface area analyses of the original COCOMAPS tool with a comprehensive and accurate atomic-level characterization of the interface, enabling detailed interpretation of molecular recognition. Furthermore, it provides a greatly enhanced flexibility, interactivity, and efficiency in graphical visualizations. Availability COCOMAPS 2.0 is accessible as a public web tool at https://aocdweb.com/BioTools/cocomaps2 and as a standalone code at https://doi.org/10.5281/zenodo.17390665 .