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Update the HOMCOS web server to enable comprehensive searching and 3D structural modeling of multimolecular complexes across all molecules in the Protein Data Bank.

August 13, 2016Journal of Structural and Functional GenomicsOpen Access

HOMCOS: an updated server to search and model complex 3D structures

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Update the HOMCOS web server to enable comprehensive searching and 3D structural modeling of multimolecular complexes across all molecules in the Protein Data Bank.
Integrated structural and binding relationship data covering proteins, nucleic acids, small compounds, and metal ions into a centralized database.
Implemented BLAST and KCOMBU algorithms to identify homologous proteins and structurally similar compounds, paired with fkcombu for flexible ligand superimposition and template-based docking.
Provided five interactive web services capable of modeling homo- and hetero-protein multimers and predicting protein-compound docking structures via rapid sequence replacement.
Delivered interactive visual outputs including Summary Bars and a Site Table interface configured to display contact residues and assess the structural impacts of mutations.

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Implication

Computational platform update demonstrates expanded 3D complex search and modeling across all Protein Data Bank molecules, highlighting streamlined structural annotation.

Cite This Study

Takeshi Kawabata (2016) studied this question.

synapsesocial.com/papers/6a86f227b688e10ffe82bb14 https://doi.org/10.1007/s10969-016-9208-y

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Implication

Computational platform update demonstrates expanded 3D complex search and modeling across all Protein Data Bank molecules, highlighting streamlined structural annotation.

HOMCOS: an updated server to search and model complex 3D structures

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Discussion

Implication

Cite This Study

HOMCOS: an updated server to search and model complex 3D structures

Key Points

Discussion

Implication

Cite This Study

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