What question did this study set out to answer?

Quantify the burden of neonatal jaundice and identify independent clinical and laboratory risk factors for severe hyperbilirubinemia in hospitalized infants.

November 30, 2025Asian Journal of Medical SciencesOpen Access

Neonatal hyperbilirubinemia in Eastern India: A comprehensive analysis of risk factors

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Authors

SCSayantani ChakrabortyR. G. Kar Medical College and Hospital OCOici ChakrabortyGovernment of Himachal Pradesh

Discussion

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Overview

Observational study reveals sepsis and hemolytic disorders drive severe hyperbilirubinemia in jaundiced neonates, highlighting the need for rapid infection control and metabolic screening.

Key Points

Quantify the burden of neonatal jaundice and identify independent clinical and laboratory risk factors for severe hyperbilirubinemia in hospitalized infants.
Enrolled 100 neonates with clinically identified jaundice admitted to an SNCU/NICU over a 1-year period in an observational descriptive study.
Collected demographic and clinical data alongside laboratory workups, including total serum bilirubin, direct Coombs test, G6PD status, liver function tests, and sepsis evaluations.
Conducted univariate and multivariate logistic regression analyses to identify independent predictors of severe hyperbilirubinemia (total serum bilirubin ≥20 mg/dL).
Severe hyperbilirubinemia occurred in 40% of the cohort (mean gestational age 37.2±2.1 weeks, mean birth weight 2.85±0.52 kg).
Sepsis was significantly associated with severe hyperbilirubinemia on univariate analysis (OR=8.78; P=0.039) and remained the strongest predictor following multivariate adjustment (aOR=7.74; P=0.066).
G6PD deficiency, rhesus incompatibility, positive direct Coombs tests, and metabolic acidosis presented exclusively in infants with severe hyperbilirubinemia.

Cite This Study

Chakraborty et al. (2025) studied this question.

synapsesocial.com/papers/69402c532d562116f2902cd8 https://doi.org/10.71152/ajms.v16i12.4825

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November 30, 2025Asian Journal of Medical SciencesOpen Access

Neonatal hyperbilirubinemia in Eastern India: A comprehensive analysis of risk factors

View Full Paper

Ask AI

Bookmark

Authors

SCSayantani ChakrabortyR. G. Kar Medical College and Hospital OCOici ChakrabortyGovernment of Himachal Pradesh

Discussion

Member takes

Overview

Observational study reveals sepsis and hemolytic disorders drive severe hyperbilirubinemia in jaundiced neonates, highlighting the need for rapid infection control and metabolic screening.

Key Points

Quantify the burden of neonatal jaundice and identify independent clinical and laboratory risk factors for severe hyperbilirubinemia in hospitalized infants.
Enrolled 100 neonates with clinically identified jaundice admitted to an SNCU/NICU over a 1-year period in an observational descriptive study.
Collected demographic and clinical data alongside laboratory workups, including total serum bilirubin, direct Coombs test, G6PD status, liver function tests, and sepsis evaluations.
Conducted univariate and multivariate logistic regression analyses to identify independent predictors of severe hyperbilirubinemia (total serum bilirubin ≥20 mg/dL).
Severe hyperbilirubinemia occurred in 40% of the cohort (mean gestational age 37.2±2.1 weeks, mean birth weight 2.85±0.52 kg).
Sepsis was significantly associated with severe hyperbilirubinemia on univariate analysis (OR=8.78; P=0.039) and remained the strongest predictor following multivariate adjustment (aOR=7.74; P=0.066).
G6PD deficiency, rhesus incompatibility, positive direct Coombs tests, and metabolic acidosis presented exclusively in infants with severe hyperbilirubinemia.

Cite This Study

Chakraborty et al. (2025) studied this question.

synapsesocial.com/papers/69402c532d562116f2902cd8 https://doi.org/10.71152/ajms.v16i12.4825

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