Prevalence of Protective Antibody Levels of IgG Against Measles, Mumps, and Rubella in Healthy Indian Adults

Background Vaccination is an important method of preventing infectious diseases. Due to waning immunity in the older age group, there are chances of acquiring vaccine-preventable diseases. The present study was undertaken to assert the seroprevalence of protective immunoglobulin G antibodies to measles, mumps, and rubella (MMR) among the healthy adult population and health care workers. Methods This prospective observational study was conducted at the outpatient Department of Internal Medicine and Blood Donation Center of the Department of Transfusion Medicine of a tertiary care center in North India over 18 months. Healthy adults without comorbidities of >18 years of age were included in the study. The levels of immunoglobulin G antibodies against MMR were tested using commercially available enzyme-linked immunosorbent assay kits (Euroimmun, Germany) by following the manufacturer's instructions. The OD ratios were calculated as per kit instructions. Results A total of 207 healthy adults were enrolled in this study. There were 175 (84.5%) males and 32 (15.5%) females. They were divided into 4 groups, group A (n = 50) adults between 18 and 39 years, group B (n = 55) adults between 40 and 59 years, and group C (n = 52) adults >60 years and group D (n = 50) health care workers (HCWs). One hundred ninety-eight (95.5%) subjects had protective antibody titers against measles. One hundred ninety-one (92.3%) subjects had protective antibody titers against rubella. One hundred seventy-one (82.5%) subjects had protective antibody titers against mumps. Eighty percent of participants reported vaccination history of measles as compared with 10% in both mumps and rubella. Around 12% and 8% of HCWs were also found to be susceptible to measles and rubella. Conclusion Overall protective immunity among adults against MMR is 95.5%, 82.5%, and 92.3%, respectively.