Clinical phenotype and prognosis of real‐world patients with wild‐type transthyretin amyloid cardiomyopathy treated with tafamidis
Key result
Tafamidis linked to ~45% lower all-cause mortality in wild-type ATTR-CM.
- HR 0.55
- 95% CI 0.39-0.77
- P=0.001
- n=1,556
Why the study?
Does tafamidis reduce all-cause mortality in real-world patients with wild-type transthyretin amyloid cardiomyopathy?
Population
1556 patients with wild-type transthyretin amyloid cardiomyopathy from 19 Italian centres. The propensity…
Comparison
Tafamidis vs Never treated with disease-modifying therapy
Design
Cohort
Follow-up
25 months (interquartile range: 15–40)
Authors
Discussion
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Implication
In a real-world cohort of patients with wild-type transthyretin amyloid cardiomyopathy, tafamidis treatment was associated with a significantly lower risk of all-cause mortality.
Study Design
Type
Cohort (n=1,556)
Multicenter
Yes
Structured PICO
Does tafamidis reduce all-cause mortality in real-world patients with wild-type transthyretin amyloid cardiomyopathy?
P
Population
1,556 real-world patients with wild-type transthyretin amyloid cardiomyopathy, analyzed via a propensity-matched cohort of 852 patients followed for a median of 25 months.
E
Exposure
Tafamidis
C
Comparator
Never treated with disease-modifying therapy
O
Outcome
All-cause mortalityhard clinical
Main Result
Hazard Ratio: 0.55 (95% CI 0.39–0.77)
p-value: p=0.001
In a real-world cohort of patients with wild-type transthyretin amyloid cardiomyopathy, tafamidis treatment was associated with a significantly lower risk of all-cause mortality.
Cite This Study
Porcari et al. (2025) conducted a cohort in Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) (n=1,556). Tafamidis vs. No disease-modifying therapy was evaluated on All-cause mortality (HR 0.55, 95% CI 0.39-0.77, p=0.001). Tafamidis treatment was associated with a significantly lower risk of all-cause mortality in patients with wild-type transthyretin amyloid cardiomyopathy (HR 0.55; 95% CI 0.39-0.77; p=0.001).