Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis
Why the study?
Echocardiography is widely utilized in ATTR-CM, but studies confirming its value for tracking changes over time were not available.
Does worsening of echocardiographic parameters over time predict mortality in patients with transthyretin amyloid cardiomyopathy?
Population
877 ATTR-CM patients attending a single centre
Comparison
Wild-type vs hereditary ATTR-CM genotypes (V122I vs T60A)
Design
Prospective observational cohort study
Follow-up
24 months
Authors
Discussion
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Member takes
Implication
Worsening MR/TR associated with mortality in ATTR-CM; hypothesis-generating for serial echo surveillance and requires prospective validation.
Structured PICO
Does worsening of echocardiographic parameters over time predict mortality in patients with transthyretin amyloid cardiomyopathy?
P
Population
877 patients with transthyretin amyloid cardiomyopathy (ATTR-CM), including 565 with wild-type and 312 with hereditary ATTR-CM (201 V122I, 90 T60A), attending a single center between 2000 and 2020.
I
Intervention
Serial echocardiography at baseline, 12 months, and 24 months
O
Outcome
Survival/mortalityhard clinical
Worsening of mitral and tricuspid regurgitation on serial echocardiography are key predictors of mortality in ATTR-CM, with the V122I genotype showing the most rapid structural and functional deterioration.
Cite This Study
Chacko et al. (2022) studied this question.