Finally aberrant splicing patterns were found in three of the four variants: BRCA1:c.80 + 3_80 + 5del, BRCA1:c.548-15G > A, BRCA2:c.8755-19 A > G that were previously classified as VUS through experimental analysis. As a result, we reclassify BRCA1;c.80 + 3_80 + 5del as LP and we classify BRCA1;c.548-15G > A and BRCA2;c.8755-19 A > G as VUS.
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Kim et al. (2025) studied this question.
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