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November 28, 2025Brain Research BulletinOpen Access

A novel brain-derived peptide inhibits microglial pyroptosis through MBTPS1 in neonatal hypoxic-ischemic brain damage

Shuai Lü Yimin Dai Zengqiang Yuan Jie Qiu

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Abstract

HIBDAP inhibits microglial pyroptosis by combining with MBTPS1 to inhibit the expression of the NLRP-3/ASC/Caspase-1/GSDMD N-terminus, IL-1β and IL-18 and significantly improves motor, learning and memory-related abilities in neonatal HIBD rats.

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Cite This Study

Lü et al. (2025) studied this question.

synapsesocial.com/papers/69402df12d562116f29040c4 https://doi.org/10.1016/j.brainresbull.2025.111664

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