This review underscores both current advances and persistent challenges in characterizing in vitro-generated RBCs, and it proposes a translational framework that integrates multi-omics data into their development and evaluation. By explicitly linking molecular regulation with process control and quality metrics, this approach provides a roadmap to optimize functional performance and ensure clinical readiness of in vitro-generated RBCs.
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Jang et al. (2025) studied this question.
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