A gold-catalyzed cyclization and amidation of 2-alkynyl arylazides with nitriles and water is described. This protocol affords structurally diverse 3-amidoindoles in moderate to excellent yields under mild reaction conditions via the key benzene-fused α-imino gold carbene intermediate. Mechanistic studies reveal that the oxygen atom in the amide group is derived from water.
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Wang et al. (2025) studied this question.
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