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We identify osteocytes as direct FSH target cells. Osteocyte Fshr deletion promotes bone turnover and accelerates fracture repair in ovariectomized mice by enhancing PI3K/Akt signaling. These findings reveal a new pathophysiological mechanism for postmenopausal osteoporosis and suggest a promising therapeutic strategy targeting FSHR.
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Zhou et al. (2025) studied this question.
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