Immunosuppressants rewire the gut microbiome-alloimmune axis through time-dependent and tissue-specific mechanisms

This is the authors' abstract. We don't add key points for this paper.

Together, our findings show that immunosuppressants elicit complex, time-dependent effects that remodel the gut and exert compartment-specific impacts on lymphoid tissues, differentially affecting gut-draining mesenteric versus peripheral LN. Understanding these relationships offers new opportunities for refining immunosuppressive strategies to reduce treatment-related off-target complications and improve long-term organ transplant outcomes.