Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials

Dong-Dong Wang; Kexin Liu; Xing Chen; Dong-Run Li; Ying Wang; Ming-Hui Sun; Rui Yang; Zhen‐Bo Feng; Xi-Yang Chen; Fang-Hua Liu; Yi-Zi Li; Fan Cao; Wei-Yi Xing; Rui-Han Bao; Ze Xing; Qi-Peng Ma; Qi Zhou; Da Li; Qi‐Jun Wu; Tingting Gong

doi:10.1186/s12916-025-04445-9

November 26, 2025BMC MedicineOpen Access

Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials

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Abstract

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This UR delineates trade-offs between ART and reproductive, perinatal, and maternal outcomes. Clinical decisions should balance effectiveness against potential risks, with future research focusing on personalized treatment strategies.

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Wang et al. (2025) studied this question.

synapsesocial.com/papers/694033db2d562116f2907b8b https://doi.org/10.1186/s12916-025-04445-9

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Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials

Abstract

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Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials

Abstract

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