How to approach and manage Lyme disease

Lyme disease is a multisystem zoonotic infection caused by Borrelia burgdorferi sensu lato, transmitted through the bite of infected Ixodes scapularis ticks. It is the most common tick-borne illness in the northern hemisphere, with growing relevance for clinical practice in the UK. This review looks at the current evidence base, with clinical guidance from the National Institute for Health and Care Excellence and international best practice to support the early recognition, accurate diagnosis and effective management of Lyme disease in primary care.