Three-Component Reaction of N-(Sulfonyl)acrylamides, Tert-Butyl nitrite, and Acetone: Preparation of Isoxazole Compounds

Herein, we present a simple, efficient, and additive-free multicomponent, tandem method for synthesizing a series of isoxazole frameworks. By using readily available N-(sulfonyl)-acrylamide with tert-butyl nitrite in acetone at 110 °C for 12 h, we successfully synthesized the target compounds. This method demonstrates excellent substrate compatibility, yielding a total of 22 target compounds, with the highest yield reaching 83%. In conclusion, the proposed method offers a reliable and straightforward approach to the synthesis of structurally diverse isoxazole frameworks.