Enantioselective synthesis of O , O -acetal-fused tetracyclic scaffolds with fluorinated tetrasubstituted centers via fluorine-assisted asymmetric induction

An asymmetric cascade reaction of fluorinated 1,3-diketones and dioxopyrrolidines achieves the synthesis of fluorinated O , O -acetal-fused tetracyclic scaffolds and clarifies fluorine's H-bond regulatory function.