Overall, the aggregated data highlight considerable methodological disparities in the existing literature and underscore the influence of psychological expectation on reported outcomes. Consequently, MSG does not commonly manifest as a significant allergen in humans, although sporadic intolerance episodes may arise in susceptible individuals. Continued research involving rigorous blinding, standardized protocols, and objective clinical endpoints is recommended to clarify any lingering uncertainties and to inform both regulatory frameworks and consumer guidance. Finally, transparent labeling could help consumers differentiate genuine allergic threats from largely anecdotal or overstated concerns, thereby promoting more balanced discourse around MSG's status in the global food industry.
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Maria Zofia Lisiecka (2025) studied this question.
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