The first Pd(II)-catalyzed vinylogous hydrocarbofunctionalization of unactivated alkenes with methyl coumarins is developed. A cleavable bidentate directing group is used to control the regioselectivity. A wide range of unactivated alkenes and methyl coumarins are viable reaction partners, providing densely functionalized coumarin derivatives generally in good yields. Moreover, a Pd(II)-catalyzed vinylogous dicarbofunctionalization of unactivated alkenes with methyl coumarins and electrophiles is also reported.
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Zhifeng Mao (2025) studied this question.
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