LCSkPOA: enabling banded semi-global partial order alignments via efficient and accurate backbone generation through extended LCSk++

The extended LCSk++ algorithm for graph structures offers a substantial advancement in sequence alignment technology. It effectively reduces memory consumption and optimizes run times without compromising alignment quality, thus providing a robust solution for all alignment modes (global, local, and semi-global) in POA. This method enhances the utility of POA in critical applications such as multiple sequence alignment for phylogeny construction and graph-based reference alignment.