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November 25, 2025Stem Cell Research & TherapyOpen Access

PBX1 promotes osteoporosis by upregulating HMGB1 to suppress osteogenic differentiation of bone marrow mesenchymal stem cells

Yang Yang Zhong Liu Yang Yang Zhong Liu

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Abstract

PBX1 acts as an upstream transcriptional regulator that suppresses osteogenic differentiation in part by activating HMGB1, and pharmacological inhibition of PBX1 restores osteogenic potential.

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Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/694039a22d562116f290b8dc https://doi.org/10.1186/s13287-025-04832-2

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1PBX1 promotes osteoporosis by upregulating HMGB1 to suppress osteogenic differentiation of bone marrow mesenchymal stem cells2025
2Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging2024 · 7 citations
3<scp>YTHDF3</scp> Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting <scp>TBX19</scp> ExpressionOriginal Research · 2026 · 1 citations
4Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis2025 · 15 citations
5Knockdown of the UL-16 binding protein 1 promotes osteoblast differentiation of human mesenchymal stem cells by activating the SMAD2/3 pathway2024

More related papers

HMGB1 as an emerging key modulator of bone remodeling: a narrative review2025
PBX1 attenuates MeHg-induced apoptosis by reducing ROS accumulation, mitigating double-strand DNA breaks, and enhancing homologous recombination DNA repair in SH-SY5Y cells2026
Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells <i>via</i> nuclear factor-κB signaling2024

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