Sustainability of Complex Interventions: Recommendations from a Pragmatic Clinical Trial to Manage Cancer Symptoms.

Sustainability is dynamic, multidimensional and emphasizes the importance of optimizing the fit of key intervention components to the care delivery context as it evolves time. Investigators are advised to plan sustainability efforts early, embrace change inherent in dynamic settings, and carefully track adaptations of intervention components to maximize intervention fit in real-world clinical practice to ensure patients continue to derive benefit from evidence-informed care.