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November 24, 2025BMC PediatricsOpen Access

Clinical application and impact of metagenomic next-generation sequencing for the diagnosis of infectious diseases in severely immunocompromised pediatric patients

Huili Shen Xiaolei Zhang Bingxue Hu Yixue Wang Bin Yang Weiming Chen Liming He Weiguo Yang Gangfeng Yan

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Abstract

mNGS exhibited superior diagnostic performance compared to CMT for diagnosing infections in critically ill children. More than half (66.0%) of mNGS tests resulted in a positive clinical impact on diagnosis and treatment, particularly among ICH patients.

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Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/69403b822d562116f290c03e https://doi.org/10.1186/s12887-025-06338-5

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