SL-based phytosomes improved psoralen dermal delivery by enhancing entrapment, penetration, and providing sustained release. These findings support phytosomal encapsulation as a promising topical delivery strategy for psoralen; however, direct bioavailability and in vivo/ex vivo validation are required to confirm therapeutic efficacy in psoriasis.
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Bhardwaj et al. (2025) studied this question.
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