The Use of the Idea of Loan Extraction to Produce a Skin Care Serum (Cosmetic) Containing a High Concentration of Bioactive Ingredients Isolated from Calendula officinalis L. Petals

In this study, the concept of loan extraction was used to design a skin care serum (cosmetic) containing high concentrations of bioactive components isolated from marigold petals. A series of extraction media derived from the final formulation were used. The effect of the type of medium on the quality of the extracts obtained was evaluated based on the physicochemical properties of the extracts and the concentrations of the extracted bioactive compounds (phenolic acids, polyphenols, amino acids, and sugars) determined by LC-MS/MS. The antioxidant potential was measured using UV-Vis methods. The final preparations were analyzed for the effect of the extract addition on physicochemical parameters (stability, viscosity, color) and anti-irritant properties. LC-MS/MS identification confirmed the presence of key phenolic metabolites of Calendula officinalis L. (including phenolic acids and flavonoids) and accompanying amino acids and sugars. The UV-Vis technique confirmed the antioxidant properties of the obtained extracts. The resulting serum shows a low value of anti-irritant potential without significantly impairing the physicochemical parameters of the product. The obtained results confirmed the possibility of direct use of Calendula officinalis L. extracts in cosmetic serum formulations, obtaining additional functional benefits.