This study underscores the significant role of relative fat mass in cognitive health, revealing a nonlinear relationship in which both high and low levels of RFM are linked to an increased risk of cognitive impairment. Given the cross-sectional design, temporal ordering cannot be established and causality cannot be inferred; our findings indicate associations between RFM and prevalent cognitive impairment and highlight the need for longitudinal confirmation in low-income rural populations.
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Guo et al. (2025) studied this question.
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