Ophthalmoplegia with ptosis represents a heterogeneous group of disorders that pose significant diagnostic challenges. We report the case of a 16-year-old adolescent boy presenting with ophthalmoplegia and unilateral ptosis. This case underscores the critical role of comprehensive clinical evaluation and standardized therapeutic protocols in the diagnosis and management of this disorder. Readers will walk through the stepwise diagnostic approach to arrive at the leading diagnosis, with a review of the possible differential diagnoses for the relevant clinical manifestations.
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Lu et al. (2025) studied this question.
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