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November 23, 2025Translational OncologyOpen Access

β-Sitosterol enhances the anti-tumor efficacy of sorafenib in hepatocellular carcinoma via the FXR/LXR/ SREBP1/ FASN pathway

Aiwen Yan Zihan Huang Kong Liang Zhaoyan Cheng Yuewen Song Xiaomao Li Pan Jiang Yuhui Yan

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Abstract

The data suggest that SIT enhances the effect of sorafenib by regulating lipid metabolism targeting FXR, LXR, SREBP1, and FASN, indicating that the strategies to union potent drugs regulating lipid metabolism with sorafenib deserves to be further explored.

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Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/69403fad2d562116f290e9a3 https://doi.org/10.1016/j.tranon.2025.102610

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Deciphering Lipid Metabolic Landscape of Sorafenib-Treated Hepatocellular Carcinoma by Mass Spectrometry Imaging and TranscriptomicsOriginal Research · 2026
2Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidationOriginal Research · 2025 · 37 citations
3Inhibiting SSBP1 enhances ferroptosis and improves the effectiveness of sorafenib treatment for liver cancer2025 · 1 citations
4The unmasking of two-faced portrait in sorafenib-resistant surroundings via systems pharmacology concept: a brightness or a silhouetteOriginal Research · 2026 · 1 citations
5Targeting CXCR6 Disrupts β-Catenin Signaling and Enhances Sorafenib Response in Hepatocellular Carcinoma2025 · 3 citations

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