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May 6, 2026BiomoleculesOpen Access

Deciphering Lipid Metabolic Landscape of Sorafenib-Treated Hepatocellular Carcinoma by Mass Spectrometry Imaging and Transcriptomics

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Authors

DLD C LiYTYuanyuan TuoLSLuheng Sai

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Overview

Mass spectrometry imaging reveals sorafenib alters lipid metabolism and immune environment in hepatocellular carcinoma.

Key Points

  • Investigate the impact of sorafenib on lipid metabolism and the immune microenvironment in hepatocellular carcinoma.
  • Used high-resolution mass spectrometry imaging to profile lipid changes in 3D HepG2 spheroids after sorafenib treatment.
  • Employed immunohistochemical and immunofluorescence techniques to evaluate immunological effects in an orthotopic mouse model.
  • Conducted transcriptomic analysis and Q-PCR for gene expression profiling.
  • Performed molecular docking to assess binding affinities relevant to lipid metabolism.
  • Sorafenib treatment caused significant changes in sphingolipid and glycerophospholipid metabolism.
  • Increased expression of immune-related genes such as Stat1 and Irf1 was observed with decreased Eif4e2 levels.
  • The treatment affected macrophage polarization and secretion of inflammatory factors in the tumor microenvironment.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b531132https://doi.org/10.3390/biom16050675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation2025 · 30 citations
  2. 2Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma2026 · 1 citations
  3. 3Transcriptomic Analysis Reveals an NRF2-Mediated Redox and Metabolic Reprogramming in Sorafenib-Resistant Hepatocellular Carcinoma Cells2026 · 2 citations
  4. 4Enhanced Apoptosis in Hepatocellular Carcinoma via Nanoscale Liposomal Codelivery of Ginsenoside CK and Sorafenib2026
  5. 5Inhibiting SSBP1 enhances ferroptosis and improves the effectiveness of sorafenib treatment for liver cancer2025