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February 12, 2026BioTechOpen Access

Transcriptomic Analysis Reveals an NRF2-Mediated Redox and Metabolic Reprogramming in Sorafenib-Resistant Hepatocellular Carcinoma Cells

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Authors

AMAngelo MichilliUniversity of FerraraCBCristian BassiUniversity of FerraraFMFarzaneh MoshiriUniversity of Ferrara

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Implication

Transcriptomic analysis reveals NRF2's role in metabolic reprogramming in HCC, suggesting new resistance-targeting strategies.

Key Points

  • This research aims to identify the molecular mechanisms contributing to sorafenib resistance in hepatocellular carcinoma.
  • Established a murine model of acquired sorafenib resistance.
  • Conducted comparative RNA sequencing of sorafenib-sensitive and -resistant HCC cells.
  • Performed pathway analysis and gene set enrichment analyses.
  • Identified 1,264 deregulated genes associated with sorafenib resistance.
  • Notable upregulation of genes regulated by NRF2 linked to antioxidant defense and metabolic rewiring.
  • Pharmacological inhibition of NRF2 with brusatol restored sorafenib sensitivity.

Cite This Study

Michilli et al. (2026) studied this question.

synapsesocial.com/papers/698d6efe5be6419ac0d54fa4https://doi.org/10.3390/biotech15010018
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