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December 16, 2025Journal of Clinical Pharmacy and TherapeuticsOpen Access

Population Pharmacokinetics of Tigecycline in Critically Ill Patients and Optimal Dosage Regimens With Dose Simulations Based on Infection Type and Renal Function

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Authors

FYFen YaoYBYunpeng BaiJZJie Zhu

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Overview

Population pharmacokinetics of tigecycline shows optimal dosing based on infection type and renal function.

Key Points

  • The aim is to develop a population pharmacokinetic model for tigecycline in critically ill patients.
  • Single-centre, prospective, observational study
  • 155 ICU patients with 458 plasma samples
  • Monte Carlo simulations for probability of target attainment calculations
  • Population PK model described tigecycline concentration–time curve
  • Clearance (CL) estimated at 16.3 L/h
  • Standard regimen insufficient for most patients; higher doses needed for certain conditions

Cite This Study

Yao et al. (2025) studied this question.

synapsesocial.com/papers/6940ac963507a57a7f7a3a34https://doi.org/10.1155/jcpt/6889748
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