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The study aims to examine the role of microtubule networks in nuclear positioning during epithelial morphogenesis in Drosophila.

December 16, 2025The Journal of Cell BiologyOpen Access

Perinuclear non-centrosomal microtubules direct nuclei dispersion during epithelial morphogenesis

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The study aims to examine the role of microtubule networks in nuclear positioning during epithelial morphogenesis in Drosophila.
Investigated the transition of microtubule networks from centrosomal to non-centrosomal during tissue morphogenesis.
Disrupted the function of CLASP, Patronin, and EB1 to assess their roles in microtubule and nuclear dispersion.
Utilized Drosophila germband as an experimental model to observe cell intercalation and extension.
Microtubule network transition is crucial for efficient nuclear dispersion during epithelial remodeling.
Disruption of CLASP and Patronin results in failed nuclear dispersion and dominance of centrosomal microtubules.
EB1 disruption impedes the necessary apical shift of non-centrosomal microtubules, causing dispersion defects.

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Findings reveal microtubule networks directing nuclear dispersion in epithelial morphogenesis in Drosophila, indicating key roles for CLASP and EB1.

Budhathoki et al. (2025) studied this question.

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Findings reveal microtubule networks directing nuclear dispersion in epithelial morphogenesis in Drosophila, indicating key roles for CLASP and EB1.