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This research examines the relationship between the NTCP rs2296651 variant and liver diseases, including hepatitis B.

The Correlation Between NTCP rs2296651 Variant and Risk of Hepatitis B, Cirrhosis, and Hepatocellular Carcinoma in Iranian Population

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This research examines the relationship between the NTCP rs2296651 variant and liver diseases, including hepatitis B.
Extracted whole blood DNA from 50 healthy individuals and 90 patients with hepatitis B, cirrhosis, and HCC.
Utilized tetra amplification refractory mutation system polymerase chain reaction (tetra-ARMS PCR) to identify genotypes of the samples.
Performed statistical analysis using SPSS software to assess associations.
Significant association found between NTCP rs2296651 and cirrhosis (P=0.002).
Positive correlation identified between cirrhosis and hepatitis B (P<0.001).
Negative relationship observed between cirrhosis and hepatocellular carcinoma (P=0.003).

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Analysis finds NTCP rs2296651 variant linked to risk of hepatitis B in Iranian population, suggesting implications for liver disease outcomes.

Akrami et al. (2025) studied this question.

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Analysis finds NTCP rs2296651 variant linked to risk of hepatitis B in Iranian population, suggesting implications for liver disease outcomes.