Study reveals disrupted functional connectivity in the auditory network of epilepsy patients, suggesting targets for cognitive intervention.
Key Points
This research aims to investigate the relationship between brain network abnormalities and verbal fluency deficits in newly diagnosed epilepsy patients.
Resting-state fMRI was conducted on 100 patients with newly diagnosed epilepsy and 54 healthy controls.
Correlation and mediation analyses evaluated links between clinical features, verbal fluency, and functional connectivity.
NDE patients showed hypo-intra-network functional connectivity in auditory, medial visual, and lateral sensorimotor networks.
Significant association found between left auditory network connectivity and verbal fluency test scores.
Functional connectivity of the inferior frontal gyrus and superior temporal gyrus mediated the relationship between seizure frequency and verbal fluency deficits.