Research reveals Notch1 signaling axis promotes radioresistance in HNSCC, suggesting targeting it may enhance radiosensitivity.
Our findings suggest that HIF-1α promotes radiotherapy resistance in HNSCC by activating the Notch1 signaling axis. Targeting this pathway may enhance radiosensitivity and provide a new strategy for overcoming hypoxia-driven resistance.
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Bao et al. (2025) studied this question.
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