Two new phenylethanol glycosides from the roots of eleutherococcus senticosus (rupr. et maxim.) maxim

Twenty-six coumarin derivatives were isolated from the roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim., including two new compounds, 4-ethyl-2-methoxyphenol-β-D-xylopyraosyl-(1″→6')-β-D-glucopyranoside (1) and 4-ethyl-2-methoxyphenol-α-L-rhamnopyranosyl-(1″→6')-β-D-glucopyranoside (2) and 24 known aromatic compounds (3-26). Structural elucidation of compounds 1-26 was confirmed by 1D and 2D NMR spectra from the literature as well as high-resolution mass spectrometric analysis. To evaluate the neuroprotective effects of all compounds on H₂O₂-induced injury in human neuroblastoma SH-SY5Y cell line, we conducted experiments. Compounds 15 and 24 showed significant protective against reduced viability of SH-SY5Y cells decreased by H₂O₂, which confirmed that they had good neuroprotective effects.