Research demonstrates enhanced treatment effectiveness in bone metastasis of nasopharyngeal carcinoma, suggesting that lipid metabolism control could improve immunotherapy results.
The synergy between the SPHK1 inhibitor PF543 and anti-programmed cell death protein 1 therapy amplified treatment effectiveness beyond standalone approaches. Overall, the SPHK1/S1P pathway advances NPC growth and aids in suppressing immune defense. Regulation of lipid metabolism may be a therapeutic target against BM in NPC and may improve the effectiveness of immunotherapy.
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Feng et al. (2025) studied this question.
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