Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption

Zuping Wu; Siqi Bao; Qian Chen; Lu Xiao; Guiwen Guan; Ruifeng Song; Qianming Chen; Xiaoyan Chen

doi:10.1016/j.identj.2025.109303

December 11, 2025International Dental JournalOpen Access

Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption

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Key Points

To explore the role of YAP dysfunction in periodontal ligament fibroblast senescence and root resorption.
Examined the impact of mechanical stress on YAP functionality.
Analyzed the activation of the cGAS/STING pathway in periodontal ligament fibroblasts.
Assessed cellular senescence markers in response to compression.
YAP dysfunction was linked to increased senescence in fibroblasts under mechanical stress.
Activation of the cGAS/STING pathway was confirmed in compressed fibroblasts.
Compression-induced root resorption was associated with enhanced fibroblast senescence.

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Implication

Findings reveal YAP dysfunction induces senescence in periodontal ligament fibroblasts, suggesting implications for root resorption mechanisms.

Abstract

Mechanical stress-induced YAP dysfunction drives PDLF senescence via cGAS/STING pathway activation, establishing a novel mechanobiological axis in root resorption.

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/6941aaf00f5af7fd17df5bfa https://doi.org/10.1016/j.identj.2025.109303

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Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption

Key Points

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Implication

Abstract

Discussion

Cite This Study

Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption

Key Points

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Implication

Abstract

Discussion

Cite This Study

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