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December 1, 2025Clinical and Translational ScienceOpen Access

No Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower‐Risk Myelodysplastic Syndromes

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Authors

ALAshley L. LennoxFHFei HuangMGMario González‐Sales

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Overview

Post hoc analysis reveals no effect of immunogenicity on efficacy or safety of imetelstat in lower-risk myelodysplastic syndromes, suggesting a stable benefit-risk profile.

Key Points

  • No association found between immunogenicity and pharmacokinetics, efficacy, or safety of imetelstat.
  • About 16.9% of patients developed anti-drug antibodies without impacting treatment outcomes.
  • Observational analysis from the phase II/III IMerge study evaluated 166 patients with lower-risk myelodysplastic syndromes.
  • Findings suggest that immunogenicity does not alter the overall benefit-risk profile of imetelstat therapy.

Cite This Study

Lennox et al. (2025) studied this question.

synapsesocial.com/papers/6941adef0f5af7fd17df5f8ahttps://doi.org/10.1111/cts.70431
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms2010 · 84 citations
  2. 2Imetelstat Achieves Meaningful and Durable Transfusion Independence in High Transfusion–Burden Patients With Lower-Risk Myelodysplastic Syndromes in a Phase II Study2020 · 125 citations
  3. 3Clinical Pharmacology Studies Supporting Oligonucleotide Therapy Development: An Assessment of Therapies Approved and in Development Between 2012 and 20182020 · 23 citations
  4. 4Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts2022 · 19 citations