What question did this study set out to answer?

To identify an acellular aqueous solution capable of precisely reproducing in vivo surface structural changes and apatite formation on bioactive glass-ceramic A-W.

June 1, 1990Journal of Biomedical Materials Research

Solutions able to reproduce in vivo surface‐structure changes in bioactive glass‐ceramic A‐W3

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Authors

TKT KokuboTakasago (Japan)HKH. KushitaniKyoto University SSS. SakkaRensselaer Polytechnic Institute

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Implication

In vitro study demonstrates that plasma-matched fluid reproduces in vivo apatite formation on glass-ceramic A-W, indicating the necessity of exact physiological ion concentrations.

Key Points

To identify an acellular aqueous solution capable of precisely reproducing in vivo surface structural changes and apatite formation on bioactive glass-ceramic A-W.
Soaked high-strength bioactive glass-ceramic A-W samples for 7 and 30 days in various acellular aqueous solutions with different ion concentrations and pH levels.
Analyzed surface structural alterations using Fourier transform infrared reflection spectroscopy, thin-film X-ray diffraction, and scanning electron microscopy compared against in vivo benchmarks.
Tris buffer solution failed to reproduce in vivo surface structural changes and did not induce apatite formation.
An aqueous solution with ion concentrations and pH matching human blood plasma (142.0 mM Na⁺, 5.0 mM K⁺, 1.5 mM Mg²⁺, 2.5 mM Ca²⁺, 148.8 mM Cl⁻, 4.2 mM HCO₃⁻, 1.0 mM PO₄²⁻ at pH 7.25) precisely replicated in vivo apatite layer formation.
Surface apatite develops through chemical reactions between the glass-ceramic and Ca²⁺, HPO₄²⁻, and OH⁻ ions present in the fluid.

Cite This Study

Kokubo et al. (1990) studied this question.

synapsesocial.com/papers/69430d5afe81bcbc9800992a https://doi.org/10.1002/jbm.820240607

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Implication

In vitro study demonstrates that plasma-matched fluid reproduces in vivo apatite formation on glass-ceramic A-W, indicating the necessity of exact physiological ion concentrations.

Solutions able to reproduce in vivo surface‐structure changes in bioactive glass‐ceramic A‐W3

Discussion

Member takes

Implication

Key Points

Cite This Study

Solutions able to reproduce in vivo surface‐structure changes in bioactive glass‐ceramic A‐W3

Discussion

Member takes

Implication

Key Points

Cite This Study

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