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December 19, 2025journal of the college of basic educationOpen Access

Cytotoxic effect of purified amylase from Bacillus licheniformis on the MCF-7 cell line

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Authors

SKSalam Muhil khafifSASawsan Hassan AuthmanAAAfrah Fahad Abdulkareem

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Overview

Cytotoxic effect reduces viability of MCF-7 breast cancer cells by 53.98%, suggesting enzyme purification could aid therapies.

Key Points

  • This research explores the potential cytotoxic effect of purified amylase from Bacillus licheniformis on MCF-7 cells.
  • Extracted and purified amylase enzyme from Bacillus licheniformis isolated from clinical and environmental sources.
  • Used ammonium sulfate precipitation, dialysis, and chromatography for purification.
  • Evaluated cytotoxic effects on MCF-7 cell line at 150µg/ml concentration.
  • 95% of Bacillus licheniformis isolates produced the amylase enzyme.
  • Purified amylase reduced cell viability of MCF-7 breast cancer cells by 53.98%.

Cite This Study

khafif et al. (2025) studied this question.

synapsesocial.com/papers/69449a892f0218eca950831chttps://doi.org/10.35950/cbej.v30i133.13971
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