STING Agonist-Loaded Cationic Radioactive Microspheres Enhance Transarterial Radioembolization of Hepatocellular Carcinoma via Tumor Immune Activation

Xin Su; Enqiao Qiao; Tian Huang; Zhengqing Lu; Weiwei Tang; Gao‐Jun Teng; Fei Xiong

doi:10.1039/d5mh01856k

December 18, 2025Materials Horizons

STING Agonist-Loaded Cationic Radioactive Microspheres Enhance Transarterial Radioembolization of Hepatocellular Carcinoma via Tumor Immune Activation

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Key Points

To investigate the effects of STING agonist-loaded cationic radioactive microspheres on TARE for HCC.
Evaluated the efficacy of cationic radioactive microspheres loaded with STING agonists.
Utilized transarterial radioembolization techniques in hepatocellular carcinoma models.
Assessed tumor immune activation as the primary mechanism of action.
STING agonist-loaded microspheres significantly enhanced tumor immune activation.
There was an improvement in TARE delivery and efficacy in treating HCC.
Investigated outcomes suggest potential for higher therapeutic effectiveness.

Implication

Demonstrates improved TARE outcomes in hepatocellular carcinoma, suggesting immune activation via cationic microspheres.

Abstract

Hepatocellular carcinoma (HCC) is a severe health condition that poses a significant threat to life, characterized by high incidence and mortality rates.Transarterial radioembolization (TARE) is expected to be a suitable...

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Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/69449a922f0218eca95086a2 https://doi.org/10.1039/d5mh01856k

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STING Agonist-Loaded Cationic Radioactive Microspheres Enhance Transarterial Radioembolization of Hepatocellular Carcinoma via Tumor Immune Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

STING Agonist-Loaded Cationic Radioactive Microspheres Enhance Transarterial Radioembolization of Hepatocellular Carcinoma via Tumor Immune Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

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