This approach demonstrates improved synthesis of indole-oxadiazole-2-amines using inexpensive electrodes and common solvents, suggesting green chemistry benefits.
A practical green and sustainable electrochemical approach has been developed for the synthesis of 5-(1H-indol-3-yl) N-substituted 1,3,4-oxadiazole-2-amines. This method utilizes inexpensive electrodes, common solvents, a range of aliphatic and aromatic isothiocyanates, demonstrating excellent functional group compatibility, medium to high yields, and a broad substrate scope.
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Kuttappan et al. (2025) studied this question.
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