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December 20, 2025Scientific ReportsOpen Access

Rapid potentiometric and spectrophotometric determination of cefotaxime in pharmaceutical and biological samples

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Authors

BABadriah Saad Al‐FarhanANAhmed H. NaggarOFOthman A. Farghaly

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Overview

Potentiometric and spectrophotometric techniques determined cefotaxime effectively in biological samples, suggesting robust analysis for pharmaceutical applications.

Key Points

  • This research aims to develop and validate rapid methods for the determination of cefotaxime in various samples.
  • Developed potentiometric and spectrophotometric methods for analysis.
  • Utilized direct titration with NaOH and a combined glass pH electrode.
  • Applied Gran plot for lower limit detection and quantification adjustments.
  • Employed Prussian Blue complex formation for spectrophotometric detection.
  • Potentiometric method detected cefotaxime down to 2.89 µg/mL with high correlation (R² = 0.9973).
  • Spectrophotometric method showed a detection limit of 0.41 µg/mL using Prussian Blue complex.
  • Recovery rates of cefotaxime varied from 95.0% to 101.6% in biological fluids and vials.

Cite This Study

Al‐Farhan et al. (2025) studied this question.

synapsesocial.com/papers/6945ea41742299010fff02b0https://doi.org/10.1038/s41598-025-31199-4
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