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The study aims to uncover how prenatal maternal immune activation affects gene expression in the offspring's amygdala.

December 20, 2025Molecular PsychiatryOpen Access

Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring

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The study aims to uncover how prenatal maternal immune activation affects gene expression in the offspring's amygdala.
Utilized a nonhuman primate model to simulate maternal immune activation during gestation.
Administered the viral mimic Poly(I:C) to pregnant macaques in early gestation.
Collected amygdala samples from offspring at 4 years and performed single-nucleus RNA sequencing.
Identified 2768 differentially expressed genes associated with prenatal immune activation in the amygdala.
DEGs concentrated in excitatory and inhibitory neurons and microglia.
Findings link prenatal immune activation with risk genes for autism and schizophrenia.

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Experimental study shows maternal immune responses disrupt gene expression in amygdala, pointing to risks for autism and schizophrenia.

Ander et al. (2025) studied this question.

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