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This research examines the impact of multi-polygenic scores on externalizing behavior in children and adolescents, considering the role of socioeconomic status.

December 22, 2025Open Access

Multi-polygenic scores for externalizing behavior in schoolchildren

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Authors

UZUxue Zubizarreta‐ArrutiVall d'Hebron Institut de Recerca MAMaría Soler ArtigasUniversitat Autònoma de Barcelona RBRosa BoschUniversitat Autònoma de Barcelona

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Implication

Analysis finds multi-polygenic score models enhance predictive accuracy for externalizing behavior in children, indicating socioeconomic factors matter.

Key Points

This research examines the impact of multi-polygenic scores on externalizing behavior in children and adolescents, considering the role of socioeconomic status.
Included 4,485 children and adolescents with behavioral and genetic data.
Externalizing behavior assessed using the Child Behavior Checklist.
Constructed polygenic scores using PRScs software.
Compared variance explained by single-PGS and multi-PGS models.
Multi-PGS models improved variance explained for externalizing behavior by 20.9% to 37.6%.
Significant interactions were found between socioeconomic status and various multi-PGS models (P-interaction < 0.05).
The influence of multi-PGSs on externalizing behavior is stronger in individuals with lower socioeconomic status.

Cite This Study

Zubizarreta‐Arruti et al. (2025) studied this question.

synapsesocial.com/papers/69488bc877063b71e748ce14 https://doi.org/10.64898/2025.12.19.25342558

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Implication

Analysis finds multi-polygenic score models enhance predictive accuracy for externalizing behavior in children, indicating socioeconomic factors matter.

Multi-polygenic scores for externalizing behavior in schoolchildren

Discussion

Member takes

Implication

Key Points

Cite This Study

Multi-polygenic scores for externalizing behavior in schoolchildren

Discussion

Member takes

Implication

Key Points

Cite This Study

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