What question did this study set out to answer?

December 22, 2025Journal of National Institute of Neurosciences Bangladesh0 citationsOpen Access

Comparative Study on the Effectiveness of Palonosetron Versus Granisetron in Preventing Postoperative Nausea and Vomiting (PONV)

MMMd Anwarul MamunNational Institute of Neurosciences & Hospital MHMd Aminul HasnatNational Institute of Neurosciences & Hospital THTayeba HaqueNational Institute of Neurosciences & Hospital

Key Points

Evaluate the effectiveness of Palonosetron versus Granisetron in preventing postoperative nausea and vomiting (PONV).
Prospective randomized trial conducted with 60 patients aged 20-50 years
Patients classified as ASA grade I and II undergoing surgery under general anaesthesia
Two groups were formed, receiving either Palonosetron or Granisetron
Overall incidence of PONV was 26.67% for Palonosetron and 63.33% for Granisetron
22 patients (73.33%) responded completely to Palonosetron compared to 11 patients (36.67%) for Granisetron
Statistical significance found with P = 0.035

Abstract

Background: Palonosetrone is a potent, single stereoisomeric 5-HT3RA, with a structure based on a fused tricyclic ring system attached to a quinuclidine moiety - unique and different from first-generation 5-HT3RA, therefore aim of our study was to find out betterment of palonosetrone as PONV management in comparison to granisetrone. Objectives: The purpose of the present study was to evaluate the effectiveness of Palonosetrone in comparison with Granisetrone in preventing Postoperative nausea and vomiting.Methodology: The patient with ASA grade I, II and age between (20-50) years undergoing surgery under general anaesthesia having no pathology or deformity causing vomiting were selected after their admission in Bangladesh Medical college and hospital from November 2019 to May 2020, Department of Anaesthesiology 11(1):52-57

Ask AI

Helpful

Bookmark

View Full Paper