Surgical Management of Solid Tumors With Hematologic Manifestations: A Mechanism‐Based Clinical Review

ABSTRACT Solid tumors can be associated with a variety of hematologic manifestations, including paraneoplastic syndromes, coagulopathy, and electrolyte derangements. Evaluation and management require a multidisciplinary approach and a clear understanding of the role and timing of surgical resection, as this can provide definitive treatment. This review summarizes current literature and offers a practical approach to stabilization and surgical‐focused management of solid tumors presenting with hematologic manifestations. The scope focuses on hematologic or metabolic paraneoplastic presentations with direct relevance to surgical timing and perioperative care; endocrine hormone excess syndromes (e.g., ectopic ACTH, SIADH) are excluded. For mechanism‐linked hematologic or metabolic manifestations, early surgical consultation is recommended. Bridge therapies enable safe anesthesia and resection, while durable correction generally requires tumor control. A standardized, age‐focused perioperative approach is integral for optimal patient outcomes.