Abstract: Background: Intestinal anastomotic leakage remains a significant clinical challenge. PRP has gained increasing attention in recent years due to its potential therapeutic benefits in various medical applications. Objective: To evaluate the effect of PRP application on outcomes of intestinal anastomosis among pediatric patients in a tertiary care hospital. Materials and Methods: This prospective cohort study was performed at Department of Pediatric Surgery, Mayo Hospital, Lahore, Pakistan, during 1st December 2024 to 30th September 2025, after obtaining ethical approval bearing number 841/RC/KEMU. After through assessment of underlying pathology intraoperatively, the surgeon decided either for conventional approach or PRP. Group P received PRP was administered between the two layers of the anastomosis whole Group C did not receive PRP application. Result: A total of 160 patients were studied with equal allocation in both of the cohorts (i.e. 80 in each cohort). Anastomosis time was significantly higher in Group P than Group C (35 versus 30, p<0.001). Anastomosis leakage (5% versus 15%, p=0.261) and adhesion related obstruction (7.5% versus 15%, p=0.480), duration of nasogastric tube (4.7±1.1 versus 5.2±1.9, p=0.090), length of hospital stay (13.1±3.4 versus 14.5±2.7, p=0.070) were lower in Group P than Group C but it did not reach statistical significance. Conclusion: The findings of the present study suggested a consistent trend towards better outcomes in the PRP group than control group in terms of anastomosis specific outcomes including anastomotic leakage and adhesions related obstruction and recovery parameters including shorter duration of nasogastric tube and length of hospital stay. The findings should be verified in a large scale, multicenter study for establishing the superiority of PRP than conventional approach. Keywords: Anastomosis leakage, Intestinal anastomosis, Platelet-rich plasma therapy, Pediatric surgery, Hyperthermia, Inflammatory disease.
Mustafa et al. (Mon,) studied this question.